Dendrimers in drug delivery and targeting: Drug-dendrimer interactions and toxicity issues

Dendrimers: Nanopharmaceuticals for Drug Delivery

Dendrimers are new class of polymeric materials. It is generally described as a macromolecule, which is characterized by its extensively branched 3D structure that provides a high degree of surface functionality and versatility. Dendrimers are highly branched, globular macromolecules with many arms emanating from a central core. The unique properties associated with these dendrimers such as uni...

drug delivery and targeting in traditional iranian pharmacy

Dendrimer: Globular Nanostructured Materials for Drug Delivery

Nanotechnology is an emerging research field that helps in reviving the structural design, synthesis and fabrication at the molecular magnitude. There are approximately 130 nanopharmaceutical products in development including~nanoparticles, nanocrystals, dendrimers, liposomes and micelles. The increase in the selectivity and stability of therapeutic agents can be achieved with the help of Nanop...

Radiation‐Sensitive Dendrimer‐Based Drug Delivery System

Combination of chemotherapy and radiotherapy is used to enhance local drug delivery while reducing off-target tissue effects. Anticancer drug doxorubicin (DOX) is loaded into l-cysteine modified G4.5 dendrimer (GC/DOX) and released at different pH values in the presence and absence of γ-radiation. Presence of γ-radiation significantly improves DOX release from the GC/DOX under acidic pH conditi...

Dendrimer - a Novel Scaffold for Drug Delivery

A dendrimer described as a macromolecule characterized by its highly branched 3D structure which provides a high degree of surface functionality and versatility. Dendrimers also referred to as the “Polymers of the 21 century.” Dendrimers components, namely (1) an initiator core (2) Interior layers (generations) composed of repeating units, radically attached to the interior core. (3) Exterior (...